Beta-Blocker Therapy for Cardiac Dysfunction in Patients With Muscular Dystrophy

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Beta-blocker therapy for cardiac dysfunction in patients with muscular dystrophy.

BACKGROUND In muscular dystrophy, cardiac function deteriorates with time and heart failure is one of the major causes of death. Although the combination of angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers improves cardiac function in adults, little is known about the efficacy of those drugs in patients with muscular dystrophy. METHODS AND RESULTS The effect of the beta-block...

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Cardiac resynchronization therapy in becker muscular dystrophy: for which patients?

University of Medicine and Dentistry of New Jersey, 401, Haddon Avenue Camden, New Jersey, USA e-mail: fayssoil2000@ yahoo.fr

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Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy.

AIMS To determine whether altered beta-adrenergic responses contribute to early cardiac dysfunction in mdx (X-linked muscular dystrophy) mice, an animal model for human Duchenne muscular dystrophy. METHODS AND RESULTS Replacement fibrosis in mdx hearts gradually increased with age, suggesting a gradual loss of cardiomyocytes. Echocardiography and intra-left ventricular haemodynamic measuremen...

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Cardiac resynchronization therapy in becker muscular dystrophy.

A 44-year-old male patient with known Becker muscular dystrophy and concomitant non-ischemic dilated cardiomyopathy presented to our department because of worsening heart failure and presyncope. Upon admission, the patient was in New York Heart Association functional class III despite optimal pharmacological treatment; his ECG showed sinus rhythm with left bundle branch block and a wide QRS com...

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Beta-blocker therapy in non-cardiac surgery.

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ژورنال

عنوان ژورنال: Circulation Journal

سال: 2006

ISSN: 1346-9843,1347-4820

DOI: 10.1253/circj.70.991